Better With Age & XYVGGR
Overview
As men age, unhealthy aging may bring cognitive decline, reduced energy, frequent mood swings, irritability, and sexual dysfunction. These changes can impact both work and daily life, leading to poor decision-making, memory problems, decreased productivity, and diminished sexual confidence. The frustration from these challenges can escalate into feelings of inadequacy and, for some, even depression. Addressing these issues early is crucial for maintaining mental sharpness, sexual vitality, and overall well-being with each chronological year.
The 9 Reasons Why Cognitive Decline, Low Energy, Mood Changes, and Sexual Dysfunction Happen with Age
As men age, several interconnected systems in the body—including the brain, hormones, energy production, and circulation—begin to slow down. Here are nine key factors that contribute to these age-related declines:
- Decline in Neurotransmitters: Essential brain chemicals like acetylcholine (important for memory), dopamine (motivation and reward), serotonin, and norepinephrine (mood regulation) decrease with age. This decline, coupled with oxidative stress, reduced testosterone, and chronic inflammation, leads to memory problems, low energy, and mood swings.
- Chronic Inflammation: Higher levels of inflammation, driven by cytokines such as IL-6 and TNF-alpha, are linked to both depression and cognitive decline. This contributes to the "inflammatory model of depression," where persistent inflammation negatively impacts mental health and brain function.
- Low Functional Testosterone: Testosterone is crucial for brain health and mood stability. As bioavailable testosterone decreases with age, it can lead to low energy, mood swings, depression, and memory issues. "Functional testosterone" focuses on maintaining the levels of testosterone that your body can actually use, rather than just looking at total levels.
- Elevated Cortisol Levels: Chronic stress raises cortisol, which can damage the hippocampus—a key brain region responsible for memory. Over time, high cortisol levels contribute to memory loss and mood disorders like depression.
- Mitochondrial Dysfunction: Mitochondria, the powerhouses of the cell, become less efficient as we age. This leads to fatigue, low energy, and worsens cognitive decline as cells lose their ability to function optimally.
- Reduced Neuroplasticity: Aging reduces the brain's ability to adapt and form new connections, known as neuroplasticity. This makes it harder to learn new things and adjust to changing environments, contributing to cognitive decline.
- Blood Flow and Vascular Health: Healthy blood vessels are essential for both erections and proper oxygen and nutrient delivery to the brain. Conditions such as heart disease, high blood pressure, and atherosclerosis can reduce blood flow to the brain and penis, causing cognitive decline and erectile dysfunction (ED).
- Nerve Function: Erection begins with nerve signals from the brain and around the penis. If nerves are damaged by conditions like diabetes, spinal injuries, or strokes, erectile dysfunction may occur. Stress, anxiety, and other mental health issues also impair nerve function.
- Nitric Oxide (NO): Nitric oxide helps relax blood vessels, improve blood flow, and influence the release of key neurotransmitters like dopamine, serotonin, and glutamate. This enhances cognition, mood, and sexual function. Nitric oxide also relaxes the penile muscles to allow blood flow and create an erection. Age-related health issues can reduce nitric oxide production, leading to cognitive dullness and difficulty achieving or maintaining erections.
Strategies to Combat Aging Brain and Body
A combination of lifestyle interventions–exercise, healthy diet, and adequate sleep– and targeted supplements with vitamins, minerals, and botanicals such as those found in Better with Age and XYVGGR can provide the body with the necessary nutrients to support healthy brain function, improve sexual vitality and optimize testosterone levels.
Functional Testosterone: A Cutting-Edge Approach to Modern Optimization
Optimal testosterone levels are commonly defined by total testosterone (T) levels, with the "optimal" range typically falling between 600 to 800 ng/dL. However, many men within this range still experience symptoms of low testosterone, such as fatigue, low libido, and diminished sexual function. For instance, a man with T levels at 800 ng/dL may feel “off,” while another may experience strong sexual vitality and energy at just 350 ng/dL. This highlights that total testosterone alone is not a reliable marker of hormonal health. A more comprehensive approach—considering free T levels, the balance between T and other hormones, healthy Leydig cells and androgen receptor sensitivity—may be essential for fully reaping the benefits of testosterone.
Functional testosterone involves looking at the overall hormonal picture rather than a single biomarker. This means considering:
- Total T: The overall testosterone levels.
- Free T and Free T Percentage: To determine how much testosterone is available to the body.
- SHBG Levels: To understand how much testosterone is bound and inactive.
- Estradiol and DHT Levels: To ensure there is no excess estrogen and DHT that could counteract the effects of testosterone.
- Ratios and Balance: Assessing the ratios between these hormones to ensure overall balance.
- Healthy Leydig Cells and Androgen Receptors – Optimal testosterone benefits rely on healthy Leydig cells in the testes and properly functioning androgen receptors (AR).
Mr. Happy Better with Age and XYVGGR: A powerful combination to function better with age.
Better with Age and XYVGGR, developed by Dr. Geo Espinosa is a comprehensive combination nutrients and botanical formula designed to enhance mood, cognition, energy and penile erections through a synergistic blend of natural ingredients. *
Better with Age ingredients:
- Curcumin (Curcuma longa): Found in turmeric, curcumin is great for brain health. It helps improve memory, reduces fatigue, and boosts mood by lowering stress and anxiety. It also protects the brain from damage thanks to its powerful anti-inflammatory and antioxidant properties.
- B Vitamins (Folate, B6, B12): These vitamins support brain health by enhancing mood and cognition. The active forms of these vitamins (like L-5-MTHF, P5P, and methylcobalamin) are more easily absorbed by the body, making them more effective in improving brain function, especially in helping with memory and mood regulation.
- Vitamin C: Known for boosting energy and mental sharpness, vitamin C improves attention and focus. It also helps the body produce neurotransmitters, the chemicals that support mood and cognitive performance.
- Vitamin D: Low vitamin D levels are linked to mood issues like depression and cognitive problems. Supplementing with vitamin D can help improve mental clarity, mood, and overall and testosterone levels.
- Velvet Bean (Mucuna pruriens): This plant contains L-Dopa, which the body converts into dopamine—a key brain chemical for motivation, focus, and mood. Mucuna pruriens also improves testosterone levels by reducing oxidative stress and enhancing testosterone production, contributing to improved reproductive health and vitality.
- L-Theanine: An amino acid found in tea, L-Theanine helps reduce stress and promotes a calm, focused mind. It increases alpha brain waves, which are linked to a relaxed yet attentive state.
- Lion’s Mane Mushroom (Hericium erinaceus): This mushroom promotes the growth of brain cells and protects the brain from damage. It’s known to support cognitive function, memory, and mood stability.
- Huperzine A: This compound helps improve memory and learning by increasing acetylcholine, a neurotransmitter involved in memory. It has also been studied for its ability to protect the brain and enhance mental alertness.
- Ashwagandha (Withania somnifera): An ancient herb used to manage stress, Ashwagandha helps reduce anxiety and balances cortisol levels. This can lead to improved mood, better focus, and more energy.
- Bacopa Monnieri: Traditionally used to boost brain function, Bacopa enhances memory and reduces anxiety. It also supports brain health with its antioxidant and anti-inflammatory properties.
- Acetyl-L-Carnitine: This nutrient supports the body’s energy production and has been shown to improve mental energy, mood, and cognitive function, particularly in older adults.
- Magnesium Glycinate: Magnesium glycinate is a highly absorbable form that helps with relaxation, mood stability, and brain function. Magnesium has been shown to positively influence testosterone levels, especially in physically active individuals, by increasing free testosterone availability.
XYVGGR ingredients:
- Selenium and Zinc: Support testicular health and reduce oxidative stress, which can boost testosterone production.
- Vitamin A and D: Essential for testicular function, improve NO production and may increase free testosterone levels.
- Ginger and Ashwagandha: Reduce inflammation and cortisol levels, potentially enhancing testosterone levels.
- Tongkat Ali and Fenugreek: May improve free testosterone levels, support overall male hormonal health and improve erectile function.
- Cordyceps: Stimulates Leydig cells, enhancing testosterone production.
- Boron: Lowers SHBG, increases free testosterone, and reduces inflammation.
- L-Citrulline: Enhances erectile function by increasing nitric oxide production, which improves blood flow. In essence, a combination of lifestyle adjustments and specific supplements can support healthy testosterone levels and improve overall male reproductive health.
Synergistic Combinations for Optimizing Functional Testosterone and Healthy Aging
As mentioned earlier, multiple hormonal factors are crucial for fully experiencing testosterone's physical and mental benefits, a concept we call functional T. These include total T, free T, testicular health, functional androgen receptors, balanced sex hormone ratios, and normal cortisol production. By combining the key ingredients found in Mr. Happy, Better with Age, and XYVGGR, you can support optimal functional testosterone. These products provide essential nutrients such as vitamins A, D, and C, along with selenium, magnesium, boron, and zinc, alongside potent botanicals like Fenugreek, Ginger, Turmeric, Tongkat Ali, Ashwagandha, Cordyceps, and Velvet Bean—together working to enhance testosterone function and overall vitality.
Holistic, Science-Backed Solutions for a Complex Problem
Slowing the aging process and maintaining optimal brain function, testosterone levels, and sexual vitality requires a comprehensive, multifaceted approach. Here, we explore the critical roles of brain chemicals, nitric oxide, and testosterone in preserving not just sexual health, but overall physical and psychological well-being. From erectile dysfunction to cognitive decline, these issues highlight the complex interplay of neural, vascular, hormonal, and psychological factors. Functional testosterone, in particular, plays a pivotal role in optimizing mood, energy, memory, and the ability to achieve and maintain an erection.
Summary on How Mr. Happy Better with Age and XYVGGR work
These nutrients and botanicals work synergistically to improve mood, brain function, and erections by:
- Enhancing neurotransmitter production and balance (serotonin, dopamine, acetylcholine).*
- Supporting mitochondrial function for energy production.*
- Optimizing functional testosterone levels. *
- Reducing inflammation and oxidative stress, which are key contributors to low energy, mood disorders, and ED.*
- Improve blood flow and Nitric Oxide production for relaxed blood vessels and stronger and more sustainable blood flow to the brain and penis.*
Mr. Happy Better with Age and XYVGGR Information:
- 90 capsules per bottle
- Quality Assurance: Manufactured in a GMP-registered facility in the U.S.A.
Recommended Use:
- Better with Age: Adults take three (3) capsules once in the morning, with or without food, or as directed by their healthcare practitioner.
- XYVGGR: Adults take three (3) capsules in the evening, two to three hours before bedtime, with or without food or as directed by your healthcare practitioner.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Reference:
1.Cai X, et.al. (2024).The effects of exergames for cognitive function in older adults with mild cognitive impairment: a systematic review and metaanalysis. Front Neurol. Jul 16;15:1424390. doi: 10.3389/fneur.2024.1424390.
2.Fotenos AF, et.al. (2008). Brain Volume Decline in Aging:Evidence for a Relation Between Socioeconomic Status, Preclinical Alzheimer Disease, and Reserve.Arch Neurol.;65(1):113–120.
3.Statsenko Y, et.al. (2022).Brain Morphometry and Cognitive Performance in Normal Brain Aging: Age- and Sex-Related Structural and Functional Changes. Front Aging Neurosci. Jan 26;13:713680.
4.Geda, Y.E. (2012). Mild Cognitive Impairment in Older Adults.Curr Psychiatry Rep14, 320–327
5.Cox, K. H., et al. (2015). The effects of turmeric (curcumin) on brain function in older adults: A randomized, placebo-controlled trial. Journal of Psychopharmacology, 29(5), 642-651.
6.Aggarwal, B. B., & Harikumar, K. B. (2009). Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune, and neoplastic diseases. The International Journal of Biochemistry & Cell Biology, 41(1), 40-59.
7.Kulkarni, S. K., & Dhir, A. (2010). An overview of curcumin in neurological disorders. Indian Journal of Pharmaceutical Sciences, 72(2), 149-154.
8.Jurenka, J. S. (2009). Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research. Alternative Medicine Review, 14(2), 141-153.
9.Sarraf P., et al. (2019). Short-term curcumin supplementation enhances serum brain-derived neurotrophic factor in adult men and women: a systematic review and dose-response meta-analysis of randomized controlled trials. Nutr Res.Sep;69:1-8.
10.Sathyabhama M., (2022). The Credible Role of Curcumin in Oxidative Stress-Mediated Mitochondrial Dysfunction in Mammals. Biomolecules. 2022 Oct 1;12(10):1405.
11.Rainey NE., et al. (2020). Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and Apoptosis. Oxid Med Cell Longev. 2020 Jul 18;2020:3656419.
12.Nunes YC., et. al. (2024) Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence. Nutrients. 2024 Aug 15;16(16):2721.
13.Seddon N., et al. (2019) Effects of curcumin on cognitive function—A systematic review of randomized controlled trials. Explor. Res. Hypothesis Med. 2019;4:1–11.
14.Small G.W. et al. (2018) Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults: A double-blind, placebo-controlled 18-month trial. Am. J. Geriatr. Psychiatry.;26:266–277.
15.Carboni L. Active Folate Versus Folic Acid: The Role of 5-MTHF (Methylfolate) in Human Health. Integr Med (Encinitas). 2022 Jul;21(3):36-41. PMID: 35999905; PMCID: PMC9380836.
16.Fava M, Mischoulon D. Folate in depression: efficacy, safety, differences in formulations, and clinical issues. J Clin Psychiatry. 2009;70 Suppl 5:12-7. doi: 10.4088/JCP.8157su1c.03. PMID: 19909688.
17.Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, Zheng Y, Tavassoli T. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022 Nov;37(6):e2852. doi: 10.1002/hup.2852. Epub 2022 Jul 19. PMID: 35851507; PMCID: PMC9787829.
18.Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016 Jan 27;8(2):68. doi: 10.3390/nu8020068. PMID: 26828517; PMCID: PMC4772032.
19.Stach K, Stach W, Augoff K. Vitamin B6 in Health and Disease. Nutrients. 2021 Sep 17;13(9):3229. doi: 10.3390/nu13093229. PMID: 34579110; PMCID: PMC8467949.
20.Song Y, Quan M, Li T, Jia J. Serum Homocysteine, Vitamin B12, Folate, and Their Association with Mild Cognitive Impairment and Subtypes of Dementia. J Alzheimers Dis. 2022;90(2):681-691. doi: 10.3233/JAD-220410. PMID: 36155508.
21.Smith, A. D., Refsum, H. (2016). Homocysteine, B Vitamins, and Cognitive Impairment. Annual Review of Nutrition, 36, 211–239.
22.Stanger, O., Fowler, B., Piertzik, K. (2009). Homocysteine, folate and vitamin B12 in neuropsychiatric disorders: Review and treatment recommendations. Expert Review of Neurotherapeutics, 9(9), 1393–1412.
23.Van Dam, F., Van Gool, W. A. (2009). Hyperhomocysteinemia and Alzheimer’s disease: A systematic review. Archives of Gerontology and Geriatrics, 48(3), 425–430.
24.Moore, E. M., Ames, D., Mander, A. G., et al. (2014). Among B vitamins, lower homocysteine to prevent cognitive decline in older adults: A randomized clinical trial. Neurology, 82(11), 909–916.
25.Reynolds, E. (2006). Vitamin B12, folic acid, and the nervous system. The Lancet Neurology, 5(11), 949-960.
26.Pokushalov E et al.Effect of Methylfolate, Pyridoxal-5'-Phosphate, and Methylcobalamin (SolowaysTM) Supplementation on Homocysteine and Low-Density Lipoprotein Cholesterol Levels in Patients with Methylenetetrahydrofolate Reductase, Methionine Synthase, and Methionine Synthase Reductase Polymorphisms: A Randomized Controlled Trial. Nutrients. 2024 May 21;16(11):1550.
27.Lam NSK et al.The potential use of folate and its derivatives in treating psychiatric disorders: A systematic review. Biomed Pharmacother. 2022 Feb;146:112541. doi: 10.1016/j.biopha.2021.112541. Epub 2021 Dec 22. PMID: 34953391.
28.Akhgarjand C et al.Does folic acid supplementation have a positive effect on improving memory? A systematic review and meta-analysis of randomized controlled trials. Front Aging Neurosci. 2022 Nov 28;14:966933.
29.May, J. M. (2012). Vitamin C transport and its role in the central nervous system. Subcellular Biochemistry, 56, 85-103.
30.Hansen, S. N., et al. (2017). Vitamin C deficiency reduces the levels of noradrenaline in the locus coeruleus and impairs memory. BMC Neuroscience, 18(1), 24.
31.Moretti, M., et al. (2013). Role of vitamin C in preventing neurodegeneration and modulating neurotransmitter homeostasis. Neuroscience Letters, 539, 82-86.
32.Brody, S. (2002). High-dose ascorbic acid increases intercourse frequency and improves mood: A randomized controlled clinical trial. Biological Psychiatry, 52(4), 371-374.
33.Talbott, S. M., & Talbott, J. A. (2012). Effect of ascorbic acid supplementation on cortisol and psychomotor performance following exhaustive exercise. The FASEB Journal, 26(S1), 1067-1067.
34.Harrison, F. E., & May, J. M. (2009). Vitamin C function in the brain: Vital role of the ascorbate transporter SVCT2. Free Radical Biology and Medicine, 46(6), 719-730.
35.Nicolas, M., et al. (2013). Vitamin C deficiency alters brain monoamine levels in dopamine-rich areas and is associated with impaired spatial memory function in male and female vitamin C-deficient mice. Journal of Nutrition and Food Sciences, 1-8.
36.Karakis, I., et al. (2016). Association of serum vitamin C levels with cognitive function and brain volume in older adults. JAMA Neurology, 73(2), 149-156.
37.Jacob, R. A., et al. (1996). Vitamin C status and mood state in young males: Effect of ascorbate depletion and supplementation. Nutrition Reports International, 35(2), 199-210.
38.McGregor, G. P., & Biesalski, H. K. (2006). Rationale and impact of vitamin C in clinical nutrition. Current Opinion in Clinical Nutrition & Metabolic Care, 9(6), 697-703.
39.Booth, A., et al. (2007). Testosterone and social behavior. Social Forces, 85(1), 167-191.
40.Maggio, M., et al. (2009). The interplay between testosterone and cortisol in cognitive aging: A review. Current Pharmaceutical Design, 15(30), 3529-3542.
41.Sim M et al. (2022). Vitamin C supplementation promotes mental vitality in healthy young adults: results from a cross-sectional analysis and a randomized, double-blind, placebo-controlled trial. Eur J Nutr.Feb;61(1):447-459.
42.Plevin D, Galletly C. (2020).The neuropsychiatric effects of vitamin C deficiency: a systematic review. BMC Psychiatry. Jun 18;20(1):315.
43.Groves, N. J., & Burne, T. H. (2017). Vitamin D, cognitive function, and mental health in the elderly. Nutrients, 9(4), 241.
44.Eyles, D. W., et al. (2013). Vitamin D and brain development. Neuroscience, 252, 241-259.
45.Patrick, R. P., & Ames, B. N. (2015). Vitamin D hormone regulates serotonin synthesis. The FASEB Journal, 29(9), 4061-4070.
46.DeLuca, G. C., et al. (2013). Cognitive impairment and vitamin D deficiency: A review and clinical perspective. BMC Neurology, 13, 65.
47.Annweiler, C., et al. (2010). Vitamin D deficiency as a risk factor for dementia: A systematic review and meta-analysis. Maturitas, 65(4), 333-338.
48.Pilz, S., et al. (2011). Vitamin D and testosterone in men. Clinical Endocrinology, 75(2), 247-255.
49.Wehr, E., et al. (2010). Association of vitamin D status with serum androgen levels in men. Clinical Endocrinology, 73(2), 243-248.
50.Wilkins CH et al. Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry. 2006 Dec;14(12):1032-40.
51.Yang T et al. Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial. J Alzheimers Dis. 2020;78(4):1509-1518. Katzenschlager, R., et al. (2004). Mucuna pruriens in Parkinson's disease: A double blind clinical and pharmacological study. Journal of Neurology, Neurosurgery & Psychiatry, 75(12), 1672-1677.
52.Manyam, B. V. (1995). Mucuna pruriens (Velvet bean) improves mood and decreases symptoms of depression through its effect on dopamine levels. International Journal of Ayurveda Research, 34(2), 112-118.
53.Shukla, K. K., et al. (2010). Mucuna pruriens reduces stress and improves the quality of semen in infertile men. Evidence-Based Complementary and Alternative Medicine, 2010, 1-9.
54.Chauhan, N. S., et al. (2011). Effect of Mucuna pruriens on serum testosterone, luteinizing hormone, follicle-stimulating hormone, and prolactin levels in infertile men. Fertility and Sterility, 92(3), 152-158.
55.Han DG et al. Anti-Inflammatory Activity of Velvet Bean (Mucuna pruriens) Substances in LPS-Stimulated RAW 264.7 Macrophages. Molecules. 2022 Dec 12;27(24):8797. doi: 10.3390/molecules27248797.
56.Tavares RL et al. (2020).Mucuna pruriens Administration Minimizes Neuroinflammation and Shows Anxiolytic, Antidepressant and Slimming Effects in Obese Rats. Molecules.Nov 26;25(23):5559.
57.Pulikkalpura,H. et al. (2015). Levodopa in Mucuna pruriens and its degradation. Sci Rep 5, 11078
58.Kimura, K., et al. (2007). L-Theanine reduces psychological and physiological stress responses. Biological Psychology, 74(1), 39-45.
59.Nobre, A. C., Rao, A., & Owen, G. N. (2008). L-Theanine, a natural constituent in tea, and its effect on mental state. Asia Pacific Journal of Clinical Nutrition, 17(S1), 167-168.
60.Giesbrecht, T., et al. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional Neuroscience, 13(6), 283-290.
61.Hidese S et al.,Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019 Oct 3;11(10):2362
62.Baba Y et al. (2021). Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study. J Med Food. Apr;24(4):333-341.
63.Li MY, et al. (2022). L-Theanine: A Unique Functional Amino Acid in Tea (Camellia sinensisL.) With Multiple Health Benefits and Food Applications. Front Nutr. 2022 Apr 4;9:853846.
64.Mori, K., et al. (2009). Hericium erinaceus (Lion's Mane) enhances neurogenesis by stimulating nerve growth factor (NGF) synthesis. Behavioural Brain Research, 199(2), 354-358.
65.Kawagishi, H., & Zhuang, C. (2008). Compounds for dementia from Hericium erinaceum (Lion's Mane). Drugs of the Future, 33(2), 149-155.
66.Nagano, M., et al. (2010). Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomedical Research, 31(4), 231-237.
67.Chiu, C.-H., et al. (2018). Neuroprotective effects of Hericium erinaceus in brain health and cognitive function. International Journal of Medicinal Mushrooms, 20(7), 607-616.
68.Martínez-Mármol R et al. (2023). Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory. J Neurochem. Jun;165(6):791-808.
69.Docherty S et al. (2023). The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study. Nutrients. Nov 20;15(22):4842
70.Li IC et al. Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Front Aging Neurosci. 2020 Jun 3;12:155.
71.Zhang, L., et al. (2002). Clinical efficacy and safety of huperzine A in treatment of Alzheimer's disease. Zhonghua Yi Xue Za Zhi, 82(14), 941-944.
72.Wang, R., et al. (2009). Huperzine A alleviates cognitive deficits caused by oxidative stress. Neuroscience Letters, 516(2), 274-278.
73.Yang, G., et al. (2001). Protective effects of huperzine A on neurons. Acta Pharmacologica Sinica, 22(7), 658-664.
74.Sun, J., et al. (2013). Effects of huperzine A on cognitive function and mood regulation. Neurobiology of Learning and Memory, 101, 64-71.
75.Chandrasekhar, K., et al. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine, 34(3), 255-262.
76.Lopresti, A. L., & Drummond, P. D. (2017). Efficacy of ashwagandha (Withania somnifera) in improving stress and anxiety: A systematic review and meta-analysis of randomized controlled trials. Journal of Clinical Medicine, 6(4), 45.
77.Wankhede, S., et al. (2015). Examining the effect of Withania somnifera supplementation on muscle strength and recovery: A randomized controlled trial. Journal of the International Society of Sports Nutrition, 12(1), 43.
78.Ahmad, M. K., et al. (2010). Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Fertility and Sterility, 94(3), 989-996.
79.Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Ann N Y Acad Sci. 2017 Aug;1401(1):49-64.
80.Kumar, R et al. Withania somnifera root extract extends lifespan of Caenorhabditis elegans. Ann. Neurosci. 2013, 20, 13.
81.Raguraman, V.; Subramaniam, J. Withania somnifera Root Extract Enhances Telomerase Activity in the Human HeLa Cell Line. Adv. Biosci. Biotechnol. 2016, 7, 199–204.
82.Stough, C., et al. (2008). The chronic effects of an extract of Bacopa monnieri (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology, 200(2), 245-252.
83.Morgan, A., & Stevens, J. (2010). Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. The Journal of Alternative and Complementary Medicine, 16(7), 753-759.
84.Russo, A., & Borrelli, F. (2005). Bacopa monniera, a reputed nootropic plant: An overview. Phytomedicine, 12(4), 305-317.
85.Bhattacharya, S. K., et al. (2000). Anxiolytic activity of Bacopa monniera: An experimental study. Phytotherapy Research, 14(3), 174-179.
86.Pettegrew, J. W., et al. (2000). Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer’s disease. Neurobiology of Aging, 21(1), 79-84.
87.Sima, A. A. F., et al. (2005). Acetyl-L-carnitine improves neuropathic pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy. Diabetes Care, 28(1), 89-94.
88.Montgomery, S. A., et al. (2003). Acetyl-L-carnitine: Metabolic support for a vulnerable system. International Journal of Neuropsychopharmacology, 6(4), 311-317.
89.Zanardi, R., et al. (2006). Acetyl-L-carnitine in depression: A long-term, double-blind, randomized, placebo-controlled trial. The Journal of Clinical Psychiatry, 67(11), 1743-1749.
90.Slutsky, I., et al. (2010). Enhancement of learning and memory by elevating brain magnesium. Neuron, 65(2), 165-177.
91.Barbagallo, M., & Dominguez, L. J. (2010). Magnesium and aging. Current Pharmaceutical Design, 16(7), 832-839.
92.Boyle, N. B., et al. (2017). The effects of magnesium supplementation on subjective anxiety and stress—a systematic review. Nutrients, 9(5), 429.
93.Veronese, N., et al. (2017). Effect of magnesium supplementation on depression: A meta-analysis. Nutrients, 9(5), 429.
94.Cinar, V., et al. (2011). The effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion. Biological Trace Element Research, 140(1), 18-23.
95.Mlynarik, M., et al. (2014). The effect of magnesium supplementation on mitochondrial function and ATP production. Journal of Bioenergetics and Biomembranes, 46(4), 343-351.
96.Johannes CB, Araujo AB, Feldman HA, et al. Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts Male Aging Study. J Urol 2000;163:460–3.
97.Lue TF. Erectile dysfunction.N Engl J Med. 2000;342:1802–1813.
98.Saenz De Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA. Impaired neurogenic and endothelium‐mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 1989; 320:
99.CunninghamGR,Stephens-ShieldsAJ,RosenRC, et al.Association of sex hormones with sexual function, vitality, and physical function of symptomatic older men with low testosterone levels at baseline in the testosterone trials. J Clin Endocrinol Metab2015;100:1146–55
100.AhnHS,ParkCM,LeeSW.The clinical relevance of sex hormone levels and sexual activity in the ageing male. BJU International2002;89:526–30.
101.El-Sakka AI. Impact of the association between elevated oestradiol and low testosterone levels on erectile dysfunction severity. Asian J Androl 2013; 15: 492–6.
102.Mancini A, Milardi D, Bianchi A, Summaria V, De Marinis L. Increased estradiol levels in venous occlusive disorder: a possible functional mechanism of venous leakage. Int J Impot Res. 2005;17:239–42.
103.Bagatell CJ, Dahl KD, Bremner WJ. The direct pituitary effect of testosterone to inhibit gonadotropin secretion in men is partially mediated by aromatization to estradiol. J Androl. 1994;15:15–21.
104.Carani C, Granata AR, Rochira V, Caffagni G, Aranda C, et al. Sex steroids and sexual desire in a man with a novel mutation of aromatase gene and hypogonadism. Psychoneuroendocrinology. 2005;30:413–7.
105.Xia, BW., Zhao, SC., Chen, ZP. et al.Relationship between serum total testosterone and prostate volume in aging men. Sci Rep11, 14122 (2021).
106.Bhasin S,Travison TG,Pencina KM, et al. Prostate Safety Events During Testosterone Replacement Therapy in Men With Hypogonadism:A Randomized Clinical Trial. JAMA Netw Open.2023;6(12):e2348692.
107.Darbandi, M., Darbandi, S., Agarwal, A. et al.Reactive oxygen species and male reproductive hormones. Reprod Biol Endocrinol16, 87 (2018).
108.Leisegang K., Henkel R. The in vitro modulation of steroidogenesis by inflammatory cytokines and insulin in TM3 Leydig cells. Reprod. Biol. Endocrinol. 2018;16:26.
109.Terburg D, Morgan B, van Honk J. The testosterone-cortisol ratio: A hormonal marker for proneness to social aggression. Int J Law Psychiatry. 2009;32(4):216–23. doi: 10.1016/j.ijlp.2009.04.008.
110.Prasad AS1, Mantzoros CS, Beck FW, Hess JW, Brewer GJ. Zinc status and serum testosterone levels of healthy adults. Nutrition. 1996 May;12(5):344-8.
111.Banihani SA. Ginger and Testosterone. Biomolecules. 2018 Oct 22;8(4):119. doi: 10.3390/biom8040119. PMID: 30360442; PMCID: PMC6316093.
112.Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol. 2009; 181(2): 741–751
113.Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012 Jul;34(3):255-62
114.Durg S., Shivaram S. B., Bavage S. (2018). Withania somnifera (Indian ginseng) in male infertility: An evidence-based systematic review and meta-analysis. Phytomedicine, 50, 247–256. doi:10.1016/j.phymed.2017.11.011
115.Leisegang K, Finelli R, Sikka SC, Panner Selvam MK. Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials. Medicina (Kaunas). 2022 Aug 4;58(8):1047.
116.Kotirum S, Ismail SB, Chaiyakunapruk N. Efficacy of Tongkat Ali (Eurycoma longifolia) on erectile function improvement: systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2015 Oct;23(5):693-8.
117.Mansoori A, Hosseini S, Zilaee M, Hormoznejad R, Fathi M. Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials. Phytother Res. 2020 Jul;34(7):1550-1555. doi: 10.1002/ptr.6627. Epub 2020 Feb 11.
118.Naghii MR, Mofid M, Asgari AR, Hedayati M, Daneshpour MS. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. J Trace Elem Med Biol.2011;25(1):54–58.